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The triple agonist mechanism appears to match or slightly exceed tirzepatide for blood sugar management , likely because the glucagon component, while it can raise blood sugar in isolation, works synergistically with GLP-1 and GIP activation to produce a net positive effect on glucose regulation

It has not been tested for safety and efficacy in food, drug, medical device, cosmetic, commercial or any other use

The dose conversion rate from IR- to ER-Tac has been calculated to +8% (138), possibly attributed to lower saturation of CYP3A and P-gp by a prolonged release in the intestine and therefore resulting in an increase of the metabolism rate ( de novo renal transplant recipients of 30%, as shown in a randomized controlled trial, the starting dose for LCP-Tac was reduced to 0.17 mg/kg/day (139)

This can lead to wrinkles, sagging, and pigmentation

Others feel the greatest benefit the following morning